Fig. 5

Stress-induced depression-like behavior in ITGB4^−/− mice. a ITGB4^−/− mice spent more time immobile in the forced swim test (n = 8). b Restraint stress for 30 min caused a drop of sucrose preference in ITGB4^−/− mice (n = 8). c, d ITGB4^−/− mice had more escape failures and a less crossing numbers in the learned helplessness test (n = 8). All data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001