Fig. 7

Proposed working model for Mrp8/14 in the development of depressive symptoms. CUMS, chronic unpredictable mild stress; Mrp8/14, myeloid-related protein-8/14; ABR-215757, N-ethyl-N-phenyl-1,2-dihydro-5-ethyl-4-hydroxyl-1-mehtyl-2-oxo-quinoline-3-carboxamide; TLR4, Toll-like receptor-4; TAK-242, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate; Hippo, hippocampus; NF-κB, nuclear factor-kappa B; ROS, reactive oxygen species; NO, nitric oxide