Fig. 11

Gro1 is markedly induced in the male hippocampus and blunted in females in response to LPS. a Western blot analysis of the hippocampus of male and female mice treated with LPS (1 mg/kg i.p., once daily for 5 days) or normal saline (NS). Five mice per group were treated. Representative blots are shown. b Intensities of protein bands were quantified from five individual mice/group, normalized to GAPDH, and presented as percent of control (NS). *p < 0.05, **p < 0.01 vs control in a post-hoc pair-wise t test. c Gro1 mRNA and d IL-1β mRNA levels in the hippocampus of LPS or NS-treated mice. NS control is taken as 1. Data are shown as mean ± SEM. Samples from five mice/group were run in triplicate and normalized against GAPDH. Results are expressed in fold change vs control (NS) taken as 1. *p < 0.05, **p < 0.01 vs control in post-hoc pair-wise t test