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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets

Fig. 5

Successive PGJ2 microinfusions induce sustained astrocyte reactivity. a TH (blue, dopaminergic) and glial fibrillary acidic protein (GFAP, green, reactive astrocytes) immunostaining shows a gradual loss of dopaminergic neurons concurring with astrocyte reactivity in the ipsilateral SNpc. Scale bar = 50 μm. b PGJ2-treated rats show significantly increased astrocyte reactivity in the ipsilateral side of the SNpc compared to controls (DMSO-treated) at 8 weeks after two (2X) injections. Values on the y-axis represent the ratios between the ipsilateral SNpc over the contralateral. Black circles, control, DMSO-treated rats; red circles, PGJ2-treated rats. Statistical significance was estimated with the Student’s T test to compare DMSO and PGJ2-treated groups, and between two PGJ2-treated groups. The p value in red indicates significant (p < 0.05) difference from DMSO-injected rats. N = 3 rats per group. X = number of injections (once per week)

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Journal of Neuroinflammation

ISSN: 1742-2094