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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells

Fig. 6

ZIKV infection activates UPR downstream genes in the mouse brain. Three-week-old AG6 mice were infected with 1 × 105 PFU/mouse (each dose, N = 3) via intraperitoneal injection. The total RNA was extracted from the nervous tissues of the mouse brains. Following the synthesis of the first strand cDNA, RT-qPCR assay was performed to assess the transcriptional levels of downstream genes of ER stress, namely, atf4, gadd34, chop, and edem-1. The relative expression levels of genes were calculated according to the 2−∆∆Ct method. Data represent three independent experiments and error bars indicate mean ± SD. Statistical analyses were performed using multiple t tests (N = 3) (P < 0.05 or P < 0.01)

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