Fig. 1

Effects of GF diets on tau pathology. Control hTau mice (a), hTau mice + rmTBI (b), hTau mice + rmTBI plus NF-216 (c, GF1), hTau mice + rmTBI plus NF-316 (d, GF2), and hTau mice + rmTBI plus NF-416 (e, GF3). Mice were fed a normal diet or diets supplemented with 2% GF for 2 months prior to rmTBI and then for 4 months after rmTBI. Animals were euthanized and subjected to immunohistochemical analysis (a–f) or Western blot analysis (g). f Graphical representation of p-tau immunohistochemistry in a–e. Each group represents mean ± SD (n = 10 per group). *p < 0.001 compared to TBI group