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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Impact of nutrition on inflammation, tauopathy, and behavioral outcomes from chronic traumatic encephalopathy

Fig. 7

Evaluation of learning (acquisition) and spatial memory retention (probe) using the Morris water maze. ad During acquisition training sessions, repetitive mTBI mice demonstrated a persistent, significant increase in escape latency acutely, subacutely, and at 1- and 6-month post-injury (p < 0.05 at all time points; Tukey). All treatments with GF diets returned the levels to normal. eh During probe trials, control and single mTBI mice demonstrated spatial memory retention, spending a significantly greater percentage of time in the target quadrant (SW), compared with all other quadrants (Min test). At the acute time point, rmTBI mice spent a similar percentage of time in all quadrants, no greater than chance, and also did not show a preference for the target quadrant, compared with the other quadrants subacutely and at 1 and 6 months post-injury (Min test). All treatments with GF diets returned the levels to normal. *p < 0.05. Values are mean ± SD. NW, northwest; NE, northeast; SE, southeast; SW, southwest

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