Fig. 4

Newborn dentate granule neurons in Tg26 mice have lower dendritic complexity and length. a Representative retroviral eGFP-labeled dentate granule neurons from WT and Tg26 mice with the Sholl analysis. Each Sholl circle increases in diameter by 10 μm from the cell soma. b Quantitative data of Sholl intersections. c–e Retroviral eGFP-labeled dentate granule neurons in WT and Tg26 mice were also assessed for total dendritic length (c), dendritic surface area (d), and dendritic volume (e). Data is presented as the mean ± SEM from four mice (three males and one female per genotype), with six to eight granule neurons being analyzed per mouse. *p < 0.05 and **p < 0.01 indicate statistical changes compared with corresponding WT granule neuron