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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Sphingosine 1-phosphate receptor subtype 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization

Fig. 4

CAY10444 (CAY) administration attenuates tMCAO-induced microglia proliferation in 3 days post-ischemic brain. Mice were challenged with tMCAO, and CAY (0.5 mg/kg) was administered intraperitoneally immediately after reperfusion. The effect of CAY on microglial proliferation was determined by BrdU/Iba1 double immunofluorescence analysis in 3 days post-ischemic brain. a Representative images of BrdU/Iba1 double-immunopositive cells in marginal zone. Scale bars, 50 μm. b Quantification of the number of BrdU/Iba1-immunopositive cells. n = 5 mice per group. ***p < 0.001 versus sham group. ##p < 0.01 versus vehicle-administered tMCAO group (tMCAO+veh)

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Journal of Neuroinflammation

ISSN: 1742-2094