New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis

Liu, Wen-Tong; Lv, Yu-Jin; Yang, Rui-Cheng; Fu, Ji-Yang; Liu, Lu; Wang, Huan; Cao, Qi; Tan, Chen; Chen, Huan-Chun; Wang, Xiang-Ru

doi:10.1186/s12974-018-1325-z

Journal of Neuroinflammation

Table 4 Significantly changed proteins in RS218-infected hBMECs

From: New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis

Accession	Description	MW [kDa]	Fold change	P value^a
O00592	Podocalyxin	58.6	1.214	0.001481**
O14556	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	44.5	2.514	0.000183***
O43598	2′-Deoxynucleoside 5′-phosphate N-hydrolase 1	19.1	0.8	0.020803*
O76024	Wolframin	100.2	0.732	0.000347***
O76095	Protein JTB	16.3	0.815	0.026287*
O95989	Diphosphoinositol polyphosphate phosphohydrolase 1	19.5	0.821	0.003332**
P05067	Amyloid beta A4 protein	86.9	0.813	0.004913**
P10412	Histone H1.4	21.9	1.271	0.001736**
P11532	Dystrophin	426.5	0.799	0.014535*
P14174	Macrophage migration inhibitory factor	12.5	1.276	0.008267**
P16401	Histone H1.5	22.6	1.221	0.025445*
P16402	Histone H1.3	22.3	1.306	0.001514**
P16403	Histone H1.2	21.4	1.332	0.021727*
P30154	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform	66.2	0.809	0.005474**
P35527	Keratin, type I cytoskeletal 9	62	0.822	0.038701*
P42167	Lamina-associated polypeptide 2, isoforms beta/gamma	50.6	0.826	0.0494*
P46781	40S ribosomal protein S9	22.6	1.207	0.013518*
P50402	Emerin	29	0.8	0.000916***
P52756	RNA-binding protein 5	92.1	0.74	4.23E−06***
P55789	FAD-linked sulfhydryl oxidase ALR	23.4	1.537	0.014932*
P61313	60S ribosomal protein L15	24.1	1.286	0.000236***
P62380	TATA box-binding protein-like protein 1	20.9	0.66	0.008696**
Q07020	60S ribosomal protein L18	21.6	1.367	0.002799**
Q4V339	COBW domain-containing protein 6	43.9	0.756	0.00457**
Q8N4H5	Mitochondrial import receptor subunit TOM5 homolog	6	1.223	0.000783***
Q8ND56	Protein LSM14 homolog A	50.5	0.793	0.017061*
Q96BZ8	Leukocyte receptor cluster member 1	30.5	0.693	0.005542**
Q96HP4	Oxidoreductase NAD-binding domain-containing protein 1	34.8	3.845	0.008111**
Q96KR1	Zinc finger RNA-binding protein	116.9	0.811	0.01368*
Q96LB3	Intraflagellar transport protein 74 homolog	69.2	0.71	0.012006*
Q96P47	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3	95	0.783	0.004713**
Q99538	Legumain	49.4	0.692	0.001173**
Q9BTA9	WW domain-containing adapter protein with coiled-coil	70.7	0.743	0.01886*
Q9BZF9	Uveal autoantigen with coiled-coil domains and ankyrin repeats	162.4	0.824	0.031539*
Q9H7B2	Ribosome production factor 2 homolog	35.6	1.367	0.020862*
Q9HCD5	Nuclear receptor coactivator 5	65.5	0.771	0.001324**
Q9NPD3	Exosome complex component RRP41	26.4	0.784	0.015931*
Q9NZR1	Tropomodulin-2	39.6	1.216	0.030742*
Q9UI10	Translation initiation factor eIF-2B subunit delta	57.5	0.828	0.001214**
Q9UIC8	Leucine carboxyl methyltransferase 1	38.4	0.811	0.0312*
Q9UK41	Vacuolar protein sorting-associated protein 28 homolog	25.4	0.715	0.032545*
Q9Y4R8	Telomere length regulation protein TEL2 homolog	91.7	0.807	0.019858*
Q9Y5V3	Melanoma-associated antigen D1	86.1	1.238	0.007536**

^aP < 0.05 (*) was considered significant, and P < 0.01 (**), as well as < 0.001 (***), were all considered extremely significant

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ISSN: 1742-2094

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