Fig. 1

LIF treatment decreases splenic LIFR but does not change spleen weight. a Western blotting was used to measure levels of the LIF receptor (LIFR) in the spleen 72 h after sham surgery and MCAO. There was a trend towards decreased LIFR levels after MCAO and a significant decrease in LIFR after MCAO and treatment with LIF (**p < 0.01). n = 8 animals per treatment group. b When LIFR protein levels were normalized to the spleen weight, there was a trend towards increased normalized LIFR in the PBS-treated group, but this increase was not significant. c At 72 h, spleen weights in the MCAO + PBS group (****p < 0.0001) and the MCAO + LIF (**p < 0.01) were significantly lower than the sham group. There was a trend towards a higher spleen weight in the MCAO + LIF group compared to the MCAO + PBS group, but this trend was not significant (p = 0.1016). n = 18–23 animals per treatment group