Fig. 13From: Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusionThe immunomodulatory effects of LIF. a Release of IL-12 from monocytes/macrophages activates the IL-12/IFNγ/IP-10 axis, b which promotes chemotaxis to the ischemic brain and increases neuroinflammation. By preventing the increase in splenic IP-10, LIF attenuates the migration of immune cells from the spleen to the ischemic brainBack to article page