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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib

Fig. 3

SIRT1 modulated the NALP1 expression following bortezomib treatment. a The photographs show double staining between SIRT1 (red) with NALP1 (green) in spinal dorsal horn on day 10 following bortezomib treatment. n = 4 in each group; scale bar, 50 μm. Intrathecal injection of resveratrol (250 μg/10 μl for 10 days) inhibited the upregulation of NALP1 mRNA (b) and protein (c) level in dorsal horn of rats on day 10 following BTZ treatment. n = 6 in each group, **P < 0.01 versus the vehicle group, ##P < 0.01 versus the corresponding BTZ group. d Intrathecal injection of SIRT siRNA increased the NALP1 expression in normal rats. n = 6 in each group, **P < 0.01 versus the control group

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