Fig. 6

IFN-γ score is an efficient candidate for prognostic indicator of glioma (a) IFN-γ score increases along with the malignancy degree of glioma based on the LGG/GBM TCGA datasets. OD, oligodendroglioma; OA, oligoastrocytoma; AST, astrocytoma; GBM, glioblastoma multiforme. The IFN-γ score (b) and CD274 (c) presented a similar pattern in both primary and non-primary glioma of various malignancies. d The IFN-γ score was correlated with the expression of PD-L1 (CD274) based on the LGG/GBM TCGA datasets. e Correlation analysis between IFN-γ score and PD-L1 expression in different parts of human glioma samples. The data were derived from the Ivy Glioblastoma Atlas Project. f The IFN-γ score was negatively correlated with the survival of glioma patients based on the LGG/GBM TCGA datasets. Unpaired Student’s t test was performed in b and c. Pearson’s correlation coefficient was performed in d and e. *p < 0.05; **p < 0.01. All values are shown as mean ± SEM