From: Circulating EZH2-positive T cells are decreased in multiple sclerosis patients
Baseline characteristics | HC | RRMS | SPMS | PPMS | Relapse |
---|---|---|---|---|---|
Initial cohort | |||||
N | 24 | 20 | 20 | 17 | 5 |
Age (years) | 30.2 (7.2) | 30.0 (7.8) | 45.7 (8.7) | 50.2 (7.3) | 30.8 (8.7) |
Female/male (% women) | 18/6 (75.0) | 10/10 (50.0) | 11/9 (55.0) | 11/6 (64.7) | 2/3 (40.0) |
Duration of disease (years) | – | 4.8 (4.6) | 11.5 (7.6) | 12.2 (7.9) | 2.2 (2.7) |
EDSSa | – | 1.7 (1.0–4.2) | 4.0 (3.5–5.1) | 6.0 (4.0–6.0) | 3.0 (2.5–5.3) |
Numbers of relapsesb | – | 2.2 (0.7) | 0.8 (0.8) | – | 2.6 (1.3) |
Validation cohort | |||||
N | 12 | 13 | |||
Age (years) | 28.2 (6.0) | 37.6 (9.3) | |||
Female/male (% women) | 8/3 (72.7) | 12/2 (85.7) | |||
Duration of disease (years) | – | 3.8 (3.2) | |||
EDSSa | – | 2.5 (1.0–3.5) | |||
Numbers of relapsesb | – | 2.5 (0.8) |