Fig. 8
From: Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice
Ibuprofen reduces early cellular damage in Atm−/− animals. Ibuprofen prevented cell cycle reentry (a–b) and DNA damage (c) in Atm−/− PCs; the pattern of nuclear translocation of HDAC4 remained unchanged (d). Similar results were observed in Atm−/− cortical neurons as measured by neuronal cell cycle activity (e–f), DNA damage (g) and nuclear HDAC4 expression (h). Ibuprofen alone did not induce any changes in Atm+/+ cerebellum (a–d) or cortex (e–h). n = 4–5 for each group. Two-way ANOVA was used for analyzing differences in genotype and ibuprofen treatment. * p < 0.05, ** p < 0.01, *** p < 0.001