Fig. 2

Peripheral effects of diet-induced obesity in mice treated with vehicle (Veh) or the TLR4 inhibitor, TAK-242 (TAK). a Baseline fasting glucose levels in male C57BL6/J mice maintained on control (CTL) and high-fat diets (HFD) and drug treatments taken at baseline (week 0) and weeks 4, 8, and 11. b Percent change in fasting blood glucose levels relative to baseline after 12 weeks of control or high-fat diet. c Glucose tolerance test showing blood glucose levels over time after administration of a glucose bolus and d area under the curve (AUC) for the glucose tolerance test. e Plasma triglyceride levels and f plasma cholesterol levels at the end of the experimental period. Data are presented as mean (±SEM) values; n = 10–14/group. For data presented across time, control diet-fed mice are shown as circles, high-fat diet-fed mice are shown as squares; vehicle-treated are open symbols, TAK-242-treated are filled symbols; for all other panels, vehicle-treated animals are shown in white bars and TAK-242-treated are shown in black bars. Statistical significance is based on ANOVA followed by Bonferroni correction. * p < 0.05 relative to drug treatment-matched mice in control diet condition