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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines

Fig. 1

Preemptive intrathecal administration of EM-1 and EM-2 attenuated CFA-induced mechanical allodynia. Preemptive intrathecal administration of EM-1 (a, 7.5, 15, and 30 nmol) and EM-2 (c, 7.5, 15, and 30 nmol) dose- and time-dependently attenuated mechanical allodynia in male mice. Each value represents mean ± S.E.M. Group size is indicated in figures. *P < 0.05, **P < 0.01, and ***P < 0.001 indicate significant differences compared with the Saline + CFA group according to two-way ANOVA followed by Bonferroni post-hoc analysis. b, d AUC was calculated during 0–7 days from dose-response curve of EM-1 or EM-2, *P < 0.05, **P < 0.01, and ***P < 0.001 indicate significant differences compared with saline according to one-way ANOVA followed by Bonferroni post-hoc analysis

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Journal of Neuroinflammation

ISSN: 1742-2094