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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines

Fig. 2

Preemptive administration of EM-1 and EM-2 robustly reduced the development of paw incision-induced mechanical allodynia. a Preemptive intrathecal administration of EM-1 (30 nmol, i.t.) and EM-2 (30 nmol, i.t.) 10 min before paw incision time-dependently attenuated mechanical allodynia in male mice. Each value represents mean ± S.E.M. Group size is indicated in figures. *P < 0.05 and ***P < 0.001 indicate significant differences compared with the Saline group according to two-way ANOVA followed by Bonferroni post-hoc analysis. b AUC was calculated during 0–4 days from time-response curve of EM-1 and EM-2, and ***P < 0.001 indicates significant differences compared with the Saline group according to one-way ANOVA followed by Bonferroni post-hoc analysis

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Journal of Neuroinflammation

ISSN: 1742-2094