Fig. 4

Evaluation of activation MM and blood brain barrier afterfocal cerebral ischemia reperfusion: a Evaluation of cerebral ischemia rat model by MRI-T2 (Four scanning imaging), as arrow (a) and 2,3-5-Triphenyltetrazolium chloride (TTC) for cerebral infarction (b). b Activation MM change 24h after focal cerebral ischemia reperfusion. Immunofluorescence staining for Iba1(red) with DAPI (blue). Left brain: cerebral infarction site. Right brain: control. c Activation MM change at 1, 7, 14, 21 days after focal cerebral ischemia reperfusion. Immunofluorescence staining for Iba1 (green) with DAPI (blue). EB extravasation in the brain as a function of BBB 24h after focal cerebral ischemia reperfusion. d The rat were injected into the tail vein with 5 ml/kg of 2% EB: Distribution of BBB disruption by extravasation of EB and (e) the amount of EB extravasation