Fig. 5
The experiment of microbubbles in vivo through ultrasound. EB extravasation in the brain as a function of BBB after US exposure (1.0 MHz, 3 W/cm2, 60 s). a Distribution of BBB disruption by extravasation of EB. Left brain: US-exposed site. b The amount of EB extravasation. c Fluorescence imaging in vivo at different time points after intravenous administration of PS-MBs (200 μl/mouse) with or without US exposure. d Quantitative analysis of fluorescence intensity for cerebral infarction site of different groups. e Immunofluorescence staining for activation M/M and fluorescence intensity of MB-labeled DiR for cerebral infarction site in different groups (*P < 0.05 versus control)