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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: The GLP-1 analog, liraglutide prevents the increase of proinflammatory mediators in the hippocampus of male rat pups submitted to maternal perinatal food restriction

Fig. 8

Increased number of Iba-1-immunopositive cells (microglia) was observed in the maternal perinatal food restriction (MPFR) model. Increased mRNA expression of proinflammatory factors: major histocompatibility complex II (MHC type II) molecules, Interleukin-1β (IL-1β), interleukin-6 (IL-6), and the transcription factor NF-κB. The administration of liraglutide to malnourished pregnant rats promoted a protective microglial phenotype in the litters, decreasing the reactivity and number of Iba-1-immunopositive cells (microglia), able of producing protective and anti-inflammatory factors: interleukin-10 (IL-10), transforming growth factor-β (TGF-β) or arginase 1 (Arg1). These effects were just observed in males

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Journal of Neuroinflammation

ISSN: 1742-2094