Skip to main content

Table 1 Effect of LPS and LPS + PLX5622 in cytokine levels in the mouse retina

From: Colony-stimulating factor 1 receptor inhibition prevents disruption of the blood-retina barrier during chronic inflammation

 

24 h

96 h

LPS

LPS + PLX5622

LPS

LPS + PLX5622

Chemokines

 CCL2

19.1***

1.46###

1.13

1.24***#

 CCL3

22***

1.32###

0.88

0.85

 CCL5

2.32***

0.48###

0.84

0.85

 CCL9

2.51**

0.59###

0.98

0.97

 CCL11

7.73***

0.55###

0.90

0.92

 CCL12

21.65***

0.76###

1.05

0.99

 CCL17

20.07***

0.94###

0.94

1.12

 CCL19

10.49***

0.69###

0.94

1.05

 CCL20

12.63***

1.16###

0.83

1.03

 CCL24

8.15***

0.60###

1.05

1.0

 CCL27

10.70***

0.67###

0.92

1.07

 CRG-2

35.83***

1.34###

0.73

0.96

 CX3CL1

17.89***

0.84###

0.85

0.83

 CXCL1

6.34***

3.16*###

1.06

1.10

 CXCL2

8.61***

0.78###

1.04

1.12

 CXCL4

9.81***

0.73###

1.07

1.10

 CXCL5

8.16***

0.99###

0.96

1.03

 CXCL9

10.51***

0.66###

0.81

0.83

 CXCL12

15.65***

0.92###

0.85

1.02

 CXCL13

13.3***

0.76###

0.86

0.96

 CXCL16

7.89***

0.72###

0.97

1.02

 XCL1

14.74***

1.09###

1.09

1.11

Growth factors

 bFGF

0.87

1.16###

3.38*

1.33#

 IGFBP-3

11.17***

0.77###

0.91

1.11

 IGFBP-5

8.79***

0.64###

0.75

0.77

 IGFBP-6

24.18***

1.28###

0.86

0.90

 G-CSF

11.25***

2.45###

0.74

0.78

 GM-CSF

25.42***

1.04###

0.87

0.95

 M-CSF

10.22***

0.8###

1.05

1.17

 VEGF

10.73***

0.68###

0.78

0.8

TNF superfamily

 CD30

40.00***

2.60###

0.83

0.88

 CD30 L

23.08***

1.10###

0.70

0.85

 CD40

67.50***

3.25###

0.94

1.08

 Fas ligand

5.48***

0.59###

0.71

0.76

 sTNFRI

5.06***

0.91###

0.89

0.93

 sTNFRII

8.39***

0.86###

0.99

0.96

 TNF-α

14.46***

0.77###

1.65

0.74

cell adhesion molecules

 I-CAM

1.40

3.29***###

1.04

1.27

 VCAM-1

1.56*

0.62###

1.58**

1.42

 L-selectin

7.77***

0.72###

0.81

0.91

 P-selectin

12.67***

0.92###

0.94

1.00

Proinflammatory cytokines

 IFN-γ

21.94***

1.25###

0.81

0.86

 IL-1α

9.05***

0.73###

0.99

0.56*#

 IL-1β

16.73***

0.8###

0.85

0.98

 IL-3

11.76***

0.3###

0.78

0.75

 IL-3 Rb

11.62***

0.59###

0.92

0.8

 IL-6

25.67***

1.22###

0.84

0.83

 IL-9

27.91***

1.17###

0.85

0.82

 IL-12 p70

16.26***

0.78###

1.00

1.12

 IL-17

29.23***

1.13###

0.90

1.06

 Leptin

14.70***

0.5###

0.85

1.04

 Leptin R

20.01***

0.67###

0.96

1.02

 TCA-3

10.25***

0.72###

1.12

1.12

 TIMP-1α

3.07***

0.70###

0.94

0.86

Anti-inflammatory cytokines

 IL-4

17.36***

0.73###

1.21

1.22

 IL-5

28.83***

1.56###

0.79

0.83

 IL-10

42***

1.05###

1.08

1.14

 IL-13

19.16***

0.88###

0.90

0.95

  1. All data are normalized to control retinas. *p < 0.05, **p < 0.01, ***p < 0.001 compared to control; #p < 0.05, ###p < 0.001 compared to LPS