| 24 h | 96 h | ||
---|---|---|---|---|
LPS | LPS + PLX5622 | LPS | LPS + PLX5622 | |
Chemokines | ||||
 CCL2 | 19.1*** | 1.46### | 1.13 | 1.24***# |
 CCL3 | 22*** | 1.32### | 0.88 | 0.85 |
 CCL5 | 2.32*** | 0.48### | 0.84 | 0.85 |
 CCL9 | 2.51** | 0.59### | 0.98 | 0.97 |
 CCL11 | 7.73*** | 0.55### | 0.90 | 0.92 |
 CCL12 | 21.65*** | 0.76### | 1.05 | 0.99 |
 CCL17 | 20.07*** | 0.94### | 0.94 | 1.12 |
 CCL19 | 10.49*** | 0.69### | 0.94 | 1.05 |
 CCL20 | 12.63*** | 1.16### | 0.83 | 1.03 |
 CCL24 | 8.15*** | 0.60### | 1.05 | 1.0 |
 CCL27 | 10.70*** | 0.67### | 0.92 | 1.07 |
 CRG-2 | 35.83*** | 1.34### | 0.73 | 0.96 |
 CX3CL1 | 17.89*** | 0.84### | 0.85 | 0.83 |
 CXCL1 | 6.34*** | 3.16*### | 1.06 | 1.10 |
 CXCL2 | 8.61*** | 0.78### | 1.04 | 1.12 |
 CXCL4 | 9.81*** | 0.73### | 1.07 | 1.10 |
 CXCL5 | 8.16*** | 0.99### | 0.96 | 1.03 |
 CXCL9 | 10.51*** | 0.66### | 0.81 | 0.83 |
 CXCL12 | 15.65*** | 0.92### | 0.85 | 1.02 |
 CXCL13 | 13.3*** | 0.76### | 0.86 | 0.96 |
 CXCL16 | 7.89*** | 0.72### | 0.97 | 1.02 |
 XCL1 | 14.74*** | 1.09### | 1.09 | 1.11 |
Growth factors | ||||
 bFGF | 0.87 | 1.16### | 3.38* | 1.33# |
 IGFBP-3 | 11.17*** | 0.77### | 0.91 | 1.11 |
 IGFBP-5 | 8.79*** | 0.64### | 0.75 | 0.77 |
 IGFBP-6 | 24.18*** | 1.28### | 0.86 | 0.90 |
 G-CSF | 11.25*** | 2.45### | 0.74 | 0.78 |
 GM-CSF | 25.42*** | 1.04### | 0.87 | 0.95 |
 M-CSF | 10.22*** | 0.8### | 1.05 | 1.17 |
 VEGF | 10.73*** | 0.68### | 0.78 | 0.8 |
TNF superfamily | ||||
 CD30 | 40.00*** | 2.60### | 0.83 | 0.88 |
 CD30 L | 23.08*** | 1.10### | 0.70 | 0.85 |
 CD40 | 67.50*** | 3.25### | 0.94 | 1.08 |
 Fas ligand | 5.48*** | 0.59### | 0.71 | 0.76 |
 sTNFRI | 5.06*** | 0.91### | 0.89 | 0.93 |
 sTNFRII | 8.39*** | 0.86### | 0.99 | 0.96 |
 TNF-α | 14.46*** | 0.77### | 1.65 | 0.74 |
cell adhesion molecules | ||||
 I-CAM | 1.40 | 3.29***### | 1.04 | 1.27 |
 VCAM-1 | 1.56* | 0.62### | 1.58** | 1.42 |
 L-selectin | 7.77*** | 0.72### | 0.81 | 0.91 |
 P-selectin | 12.67*** | 0.92### | 0.94 | 1.00 |
Proinflammatory cytokines | ||||
 IFN-γ | 21.94*** | 1.25### | 0.81 | 0.86 |
 IL-1α | 9.05*** | 0.73### | 0.99 | 0.56*# |
 IL-1β | 16.73*** | 0.8### | 0.85 | 0.98 |
 IL-3 | 11.76*** | 0.3### | 0.78 | 0.75 |
 IL-3 Rb | 11.62*** | 0.59### | 0.92 | 0.8 |
 IL-6 | 25.67*** | 1.22### | 0.84 | 0.83 |
 IL-9 | 27.91*** | 1.17### | 0.85 | 0.82 |
 IL-12 p70 | 16.26*** | 0.78### | 1.00 | 1.12 |
 IL-17 | 29.23*** | 1.13### | 0.90 | 1.06 |
 Leptin | 14.70*** | 0.5### | 0.85 | 1.04 |
 Leptin R | 20.01*** | 0.67### | 0.96 | 1.02 |
 TCA-3 | 10.25*** | 0.72### | 1.12 | 1.12 |
 TIMP-1α | 3.07*** | 0.70### | 0.94 | 0.86 |
Anti-inflammatory cytokines | ||||
 IL-4 | 17.36*** | 0.73### | 1.21 | 1.22 |
 IL-5 | 28.83*** | 1.56### | 0.79 | 0.83 |
 IL-10 | 42*** | 1.05### | 1.08 | 1.14 |
 IL-13 | 19.16*** | 0.88### | 0.90 | 0.95 |