Fig. 1

Study design. a Experiment 1: TFC test training was performed 1 day before surgery. Mice in the Con+anti-IL-17A group received i.p. anti-IL-17A Abs, and the Con+isotype group received an equivalent dose of isotype-control Abs 30 min before surgery. Behavioural tests included TFC and the Y maze performed 24 h after surgery, and then the hippocampi were collected. b Experiment 2: After behavioural tests, the mice received an intravenous injection of EB, and the hippocampi were collected for EB extravasation detection