Fig. 6

Knocking down of βCaMKII in CA1 rescued depression-like behaviors of depressed rats. a Schematics of AAV vectors engineered to overexpress a control construct or RNAi form of βCaMKII. H1, human H1 promoter. b Experimental paradigm for behavioral testing of rats infected by virus. c Illustration of viral infusion of βCaMKII RNAi construct into the CA1. Scale bar is 200 μm. d, e Behavioral effects after expressing AAV-βCaMKII RNAi construct within the CA1 of depressed rats. N = 18 per group. Data are presented as the means ± SEM. *P < 0.05, **P < 0.01 CUMS+AAV-βi vs CUMS; ^#P < 0.05, ^##P < 0.01 CUMS+AAV-βi vs CUMS+AAV-control (AAV-βi, AAV-βCaMKII RNAi)