Fig. 1

Summary of experimental design for the three major phases of the study. a Characterization of responses of Iba1-positive cells in peri-infarct tissue during the first week following photothrombotic stroke. The numbers of rats shown were all assessed using the forelimb placing test. Perfusion-fixed tissue from four to six rats per time point was used to assess infarct volume and that from four rats per time point was used for immunohistochemistry. b Effects of lower-dose minocycline treatment on forelimb function and cellular changes during the first week following photothrombotic stroke. c Effects of higher-dose minocycline treatment on forelimb function (up to 28 days) and cellular changes following photothrombotic stroke