|
Validated positive hit
|
BDNF production
|
Microglia migration
|
|---|
|
RhoE/Rnd3
|
Reduced, p<0.01
|
Enhanced, p<0.01
|
|
Tiam1
|
Not affected
|
Enhanced, p<0.01
|
|
p38β/Mapk11
|
Reduced, p<0.05
|
Not affected
|
|
GM-CSFR/Csf2ra
|
Not affected
|
Not affected
|
|
Map3k2
|
Not affected
|
Not affected
|
|
Creb1
|
Reduced, p<0.001
|
Not affected
|
|
IκBα/Nfkbia
|
Not affected
|
Enhanced, p<0.01
|
- Primary microglia were transfected with validated siRNA oligonucleotides against their indicated target protein and tested for their effect on BDNF expression and microglia migration as described in Figs. 3 and 4
