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Table 2 Summary of the secondary screens

From: The atypical RhoGTPase RhoE/Rnd3 is a key molecule to acquire a neuroprotective phenotype in microglia

Validated positive hit

BDNF production

Microglia migration

RhoE/Rnd3

Reduced, p<0.01

Enhanced, p<0.01

Tiam1

Not affected

Enhanced, p<0.01

p38β/Mapk11

Reduced, p<0.05

Not affected

GM-CSFR/Csf2ra

Not affected

Not affected

Map3k2

Not affected

Not affected

Creb1

Reduced, p<0.001

Not affected

IκBα/Nfkbia

Not affected

Enhanced, p<0.01

  1. Primary microglia were transfected with validated siRNA oligonucleotides against their indicated target protein and tested for their effect on BDNF expression and microglia migration as described in Figs. 3 and 4