Fig. 2
From: A review of the role of cav-1 in neuropathology and neural recovery after ischemic stroke
The role of cav-1 in angiogenesis and neurogenesis. Cav-1 is essential for NO-mediated angiogenesis and VEGF-induced angiogenesis. VEGF can promote NO production and NO can increase the expression of VEGF. Cav-1/VEGF-dependent pathway is important for neurogenesis, and cav-1 enhances NMDAR (P-Src, P-CaMKII, P-ERK1/2), TrkB signaling (P-TrkB, P-Akt), and PKA signaling, and augments dendritic growth and arborization. Methyl-D-aspartate receptor (NMDAR), calcium/calmodulin-dependent protein kinase II (CaMKII), phosphorylated (P)-extracellular signal-regulated kinase (ERK), tyrosine kinase B receptor (TrkB), cAMP-dependent protein kinase (PKA)