Fig. 5
Repeated CXCL1 neutralizing antibody and NFκB inhibitor treatment attenuates mechanical allodynia caused by BCP. a BCP induced significant mechanical allodynia as shown by von-Frey tests. Injection of 8 μg/0.5ul and 4 μg/0.5ul CXCL1 neutralizing antibody showed an effective and reliable anti-allodynic effect in a dose-dependent manner on BCP. Drugs were given once a day from POD 6 to POD 9. n = 8, ***p < 0.001, **p < 0.01 compared with that of BCP + control serum group. ###p < 0.001, ##p < 0.01 compared with that of BCP + CXCL1 neutralizing antibody 4 μg group. There were eight rats in each group. b Repeated BAY11-7082 treatment at 1 μg showed no effect on mechanical allodynia, but 10 μg of this compound significantly attenuated mechanical allodynia (***p < 0.001, **p < 0.01 vs. BCP + PBS group; n = 8)