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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Crosstalk between NFκB-dependent astrocytic CXCL1 and neuron CXCR2 plays a role in descending pain facilitation

Fig. 7

VlPAG micro-injection of CXCL1 induces mechanical allodynia via CXCR2. a Micro-injection of CXCL1 (10 or 100 ng) induces a dose-dependent mechanical allodynia. n = 8, ***p < 0.001 **p < 0.01 versus PBS; ###p < 0.001 versus CXCL1 10 ng. b Micro-injection of CXCR2 antagonist, SB225002, 30 min before CXCL1 vlPAG injection dose-dependently prevented CXCL1-induce mechanical allodynia. n = 8, ***p < 0.001 versus corresponding BL (baseline); ###p < 0.001 versus 5%DMSO + CXCL1 (100 ng); @@@p < 0.001 @p < 0.05 versus SB225002 (5 μg) + CXCL1 (100 ng)

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Journal of Neuroinflammation

ISSN: 1742-2094