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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: The TRPC6 inhibitor, larixyl acetate, is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction

Fig. 3

129S and 129S-C57BL/6-F2 mice exhibit similar TBI-associated aortic endothelial dysfunction as the one observed in C57BL/6 mice. a, d Summary data for the active tensions measured in the presence of 70 mM KCl in aortic arch rings from sham or TBI mice. b, e Concentration-response relationships for phenylephrine-induced contractions in aortic arch rings from sham and TBI mice. c, f Concentration-response relationships for acetylcholine-induced dilations in phenylephrine-precontracted rings from sham and TBI 129S-TRPC1 knockout mice. The insets in b, c, e, and f show the sample traces of active tension changes in aortas from sham (black lines) and TBI (red lines) mice. PE - phenylephrine, ACh - acetylcholine

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Journal of Neuroinflammation

ISSN: 1742-2094