Fig. 4

129S-TRPC1 knockout mice exhibit similar TBI-associated aortic endothelial dysfunction as the one observed in the control wild type 129S mice. a Summary data for the active tensions measured in the presence of 70 mM KCl in aortic arch rings from sham or TBI TRPC1 knockout mice. b Concentration-response relationships for phenylephrine-induced contractions in aortic arch rings from sham and TBI 129S-TRPC1 knockout mice. c Concentration-response relationships for acetylcholine-induced dilations in phenylephrine-precontracted rings from sham and TBI 129S-TRPC1 knockout mice. The insets in b and c show the sample traces of active tension changes in aortas from sham (black lines) and TBI (red lines) mice. PE - phenylephrine, ACh - acetylcholine