Fig. 6

Pharmacological inhibition of TRPC6 in 129S-C57BL/6-F2 and C57BL/6 mice prevented TBI-associated aortic endothelial dysfunction. a, d Summary data for the active tensions measured in the presence of 70 mM KCl in aortic arch rings from TBI 129S-C57BL/6-F2 or C57BL/6 mice treated in vivo with DMSO or larixyl via intraperitoneal injection at 5 mg/kg/day daily for 7 days. b Concentration-response relationships for phenylephrine-induced contractions in aortic arch rings from TBI 129S-C57BL/6-F2 mice treated with DMSO or larixyl acetate in vivo. c Concentration-response relationships for acetylcholine-induced contractions in phenylephrine-precontracted rings from sham and TBI 129S-C57BL/6-F2 mice treated with DMSO or larixyl in vivo. e Concentration-response relationships for phenylephrine-induced contractions in aortic arch rings from TBI C57BL/6-F2 mice treated with DMSO or larixyl acetate in vivo. f Concentration-response relationships for acetylcholine-induced contractions in phenylephrine-precontracted rings from sham and TBI C57BL/6 mice treated with DMSO or larixyl in vivo. The insets in b, c, e, and f show the sample traces of active tension changes in aortas from the TBI-DMSO group (black lines) and TBI-larixyl group (red lines) mice. PE - phenylephrine, ACh - acetylcholine