Fig. 1
From: Neuroinflammation and fractalkine signaling in Alzheimer’s disease
Diagrammatic representation of FKN and proteolytic cleavage fragments. a Full-length FKN variant is membrane-associated protein with a short cytoplasmic domain, a single transmembrane domain, and an extracellular mucin-like stalk and chemokine domain. b Soluble FKN (sFKN). Putative ADAM10/17 cleavage variant, generating a soluble FKN that includes the mucin-like stalk. c A theoretical fragment of FKN containing only the chemokine domain. This peptide is typically used for recombinant peptide studies