Fig. 7
IFNβ1a effects on inflammatory cytokines in the hippocampus. a, b Hippocampal levels of pro-inflammatory cytokines, IL-1β and IL-6. Note that IL-1β and IL-6 levels were significantly increased in the Aβ1-42 group (n = 5 respectively) and this increase was counteracted by treatment with IFNβ1 (n = 5 respectively) in the Aβ1-42 + IFNβ1a group (n = 5 respectively). c, d Hippocampal levels of anti-inflammatory cytokines, IL-10 and TGF-β1. Note IL-10 and TGF-β1 levels showed significant reduction in the Aβ1-42 group (n = 5 respectively) and following IFNβ1a (n = 5, respectively) treatment in the Aβ1-42 + IFNβ1a group (n = 5, respectively) were recovered to control (n = 5 and n = 6, respectively) levels. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001