Fig. 8
IFNβ1a effects on ROS and lipid peroxidation levels and SOD1 or SOD2 proteins and activity levels in the hippocampus. a, b The levels of SOD1 showed significant increase in the Aβ1-42 + IFNβ1a group (n = 5), whereas those of SOD2 appear significantly reduced in the same group (n = 5). c Total SOD activity levels showed significant decrease in Aβ1-42 group (n = 5), and this decrease was counteracted in the Aβ1-42 + IFNβ1a group (n = 5) by treatment with IFNβ1a. d ROS levels were significantly increased in the Aβ1-42 group (n = 5), and this increase was counteracted by treatment with IFNβ1a (n = 5). e The analysis of lipid peroxidation levels, measured as concentration of MDA, revealed a significant increase of MDA levels in the Aβ1-42 group (n = 5) that was completely blocked by IFNβ1a treatment in the Aβ1-42 + IFNβ1a group (n = 5). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001