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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Co-inhibition of PGF and VEGF blocks their expression in mononuclear phagocytes and limits neovascularization and leakage in the murine retina

Fig. 2

Effects of PGF and VEGF inhibition on choroidal neovascularization. a Representative images of lectin-stained RPE/choroidal flat mounts of animals of all treatment groups 3 and 7 days after laser damage. Dashed lines indicate CNV areas, and the asterisks mark the optic nerve head. Scale bare: 100 μm. b Quantification of lectin-stained CNV areas in RPE/choroidal flat mounts 3 days after laser coagulation with ZEN software (n = 10 eyes for IgG, n = 10 eyes for aVEGF, n = 11 eyes for aPGF, n = 11 eyes for aVEGF/aPGF, n = 10 eyes for aflibercept). c Quantification of lectin-stained CNV areas in RPE/choroidal flat mounts 7 days after laser coagulation with ZEN software (n = 14 eyes for IgG, n = 13 eyes for aVEGF, n = 14 eyes for aPGF, n = 16 eyes for aVEGF/aPGF, n = 28 eyes for aflibercept). Data are shown as mean ± SEM (*P < 0.05, **P < 0.01, ***P < 0.001)

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Journal of Neuroinflammation

ISSN: 1742-2094