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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Semaphorin4A causes loss of mature oligodendrocytes and demyelination in vivo

Fig. 5

Sema4A causes an increase in locally activated microglia. The brain tissue slices were stained for Iba1, a microglial marker, GFAP, an astrocytic marker, and CD3, a pan-lymphocyte marker. a PBS injection does not affect Iba1 signal. b Sema4A injection causes an increase in Iba1 signal of 223% (c). Both PBS (d) and Sema4A (e) had no effect on astrocyte numbers, as indicated by non-significant differences in GFAP staining. Furthermore, CD3 signal was not increased in the PBS (g) or Sema4A (h) injection groups. PBS and Sema4A groups had n = 5. Unpaired t tests were used to compare PBS and Sema4A groups; *p < 0.05

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