Fig. 1

Laquinimod therapy activates NK cells. a Representative flow cytometry analysis of NK1.1/CD69 expression and quantification of activating and inhibitory NK cell receptors on day 11 after immunization with MOG_35–55 and laquinimod (blue bars) or vehicle therapy (gray bars). Data are presented as mean ± S.E.M. and are representative of two independent experiments with five animals/group. **P < 0.01, ***P < 0.001, ****P < 0.0001, unpaired t test with Welch’s correction. b Representative flow cytometry analysis of splenic NK cell subsets defined by CD27/CD11b expression on day 11 after laquinimod or vehicle therapy of MOG_35–55-immunized animals. Data are presented as mean ± S.E.M. and are pooled from three independent experiments with nine animals/group. **P < 0.01, ***P < 0.001, unpaired t test. c Quantification of CD69 expression by flow cytometry on NK cell subsets. Data are presented as mean ± S.E.M. and are representative of two independent experiments with five animals/group. **P < 0.01, ***P < 0.001 unpaired t test