Table 1 Orexin A treatment increases the total numbers of immune cells in draining lymph nodes during EAE

Myeloid cells

CD11b⁺

1.96 ± 0.3 × 10⁴

19.44 ± 3.7 × 10⁴

57.37 ± 11.5 × 10⁴*

CD11c⁺

3.96 ± 0.7 × 10⁴

7.13 ± 2.1 × 10⁴

32.94 ± 6.0 × 10⁴*

CD11b⁺CD11c⁺

1.97 ± 0.3 × 10⁴

7.38 ± 2.1 × 10⁴

27.09 ± 4.5 × 10⁴*

Ly6G⁺Ly6C^low

3.92 ± 1.1 × 10⁴

5.24 ± 0.9 × 10⁴

22.65 ± 5.1 × 10⁴*

Ly6G⁻Ly6C^high

0.31 ± 0.08 × 10⁴

9.59 ± 1.9 × 10⁴

22.61 ± 4.6 × 10⁴*

CD4⁺ cells

CD4⁺

1.63 ± 0.2 × 10⁶

2.15 ± 0.4 × 10⁶

5.51 ± 0.8 × 10⁶ *

Ki67⁺

8.92 ± 1.3 × 10⁴

33.41 ± 8.8 × 10⁴

95.39 ± 14.6 × 10⁴ *

CD69⁺

8.93 ± 1.2 × 10⁴

4.26 ± 1.2 × 10⁴

9.61 ± 4.1 × 10⁴

CD44⁺CD62L⁺ (Tcm)

11.47 ± 1.7 × 10⁴

23.97 ± 5.8 × 10⁴

57.31 ± 8.4 × 10⁴ *

CD44⁺CD62L⁻ (Tem)

9.83 ± 1.0 × 10⁴

149.7 ± 28.1 × 10⁴

394.7 ± 64.9 × 10⁴ *

CD44⁻CD62L⁺ (Tn)

137.0 ± 20.0 × 10⁴

34.21 ± 8.5 × 10⁴

80.32 ± 12.84 × 10⁴ *

Tregs

16.10 ± 1.9 × 10⁴

28.88 ± 6.7 × 10⁴

72.92 ± 10.8 × 10⁴ *

Ki67⁺Tregs

8.20 ± 1.0 × 10⁴

10.73 ± 2.7 × 10⁴

26.48 ± 4.1 × 10⁴*

CD8⁺ cells

CD8⁺

1.36 ± 0.2 × 10⁶

1.87 ± 0.4 × 10⁶

4.28 ± 0.7 × 10⁶ *

Ki67⁺

61.54 ± 9.0 × 10⁴

16.59 ± 4.2 × 10⁴

45.13 ± 6.5 × 10⁴ *

CD69⁺

6.16 ± 0.8 × 10⁴

4.23 ± 1.3 × 10⁴

8.34 ± 3.3 × 10⁴

CD44⁺CD62L⁺ (Tcm)

20.69 ± 2.5 × 10⁴

34.0 ± 10.5 × 10⁴

70.94 ± 14.7 × 10⁴

CD44⁺CD62L⁻ (Tem)

1.16 ± 0.1 × 10⁴

144.2 ± 26.7 × 10⁴

333.5 ± 53.8 × 10⁴ *

CD44⁻CD62L⁺ (Tn)

112.8 ± 16.8 × 10⁴

3.43 ± 0.7 × 10⁴

9.24 ± 1.4 × 10⁴*