Fig. 4

UA alleviated brain Aβ burden in APP/PS1 mice. a Representative images of Aβ42 deposits in the cerebral cortex and hippocampus. Scale bar = 250 μm. b Representative images of Aβ40 deposits in the cerebral cortex and hippocampus. Scale bar = 250 μm. c, d Quantification of Aβ area in the hippocampus and cerebral cortex, n = 8–10 mice per group, three sections per animal. e, f Quantification of the number of Aβ deposits in the cerebral cortex and hippocampus. g, h Levels of soluble Aβ40 and Aβ42 were measured by ELISA, n = 4 mice per group. Data are presented as the mean ± SEM, *P < 0.05 and **P < 0.01. WT wild-type, UA urolithin A