Skip to main content

Table 2 Association between blood cell counts and derived ratios, and risk of all-cause dementia

From: Balance between innate versus adaptive immune system and the risk of dementia: a population-based cohort study

Laboratory assessment#

All-cause dementia

(n/N = 664/8313)

 

Model I

Model II

 

HR (95% CI)

HR (95% CI)

Granulocytes

1.14 (0.87–1.50)

1.07 (0.80–1.43)

 Corrected for platelets and lymphocytes

1.33 (0.99–1.79)

1.22 (0.89–1.67)

Platelets

1.48 (1.11–1.96)*

1.43 (1.08–1.90)*

 Corrected for granulocytes and lymphocytes

1.48 (1.10–2.00)*

1.45 (1.07–1.95)*

Lymphocytes

0.80 (0.64–0.99)*

0.81 (0.64–1.03)

 Corrected for granulocytes and platelets

0.76 (0.61–0.96)*

0.78 (0.62–1.00)

Granulocyte-to-lymphocyte ratio

1.34 (1.10–1.63)*

1.26 (1.03–1.53)*

Platelet-to-lymphocyte ratio

1.29 (1.08–1.55)*

1.27 (1.05–1.53)*

Systemic immune-inflammation index

1.18 (1.02–1.39)*

1.15 (0.98–1.34)

  1. Abbreviations: CI confidence interval, HR hazard ratio, n number of incident dementia events, N number of participants for analysis. Model I is adjusted for age and sex. Model II is adjusted for age, sex, education, smoking status, body mass index, diabetes mellitus, history of stroke, and APOE4 ε4 carrier status
  2. #All types of blood cells and their derived ratios were natural logarithmic transformed
  3. *Indicates statistically significant result