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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice

Fig. 6

Neuronal CCL2 and CX3CL1 expression is modulated by TGFβ1-mediated signaling. a Relative CCL2 mRNA expression of HT-22 cells treated with recombinant TGFβ1, GW788388, or SIS3. b CCL2 concentrations in HT-22 cell media treated with recombinant TGFβ1, GW788388, or SIS3. c Relative CX3CL1 mRNA expression of HT-22 cells treated with recombinant TGFβ1, GW788388, or SIS3. d CX3CL1 concentrations in HT-22 cell media treated with recombinant TGFβ1, GW788388, or SIS3. *p < 0.05 compared to basal HT-22 cells. #p < 0.05 compared to TGFβ1-treated HT-22 cells. n = 3 for mRNA analyses and n = 4 for ELISA analyses

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Journal of Neuroinflammation

ISSN: 1742-2094