Skip to main content
Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice

Fig. 7

Microglia activation is induced by secreted factors from TGFβ1-stimulated neurons. a Relative IL-1β and (b) TNFα mRNA expression in EOC-20 cells supplemented with conditioned media from HT-22 cells treated with recombinant TGFβ1, GW788388, or SIS3. c Phagocytosis activity, reported as fluorescence intensity of phagocytized E. coli bioparticles, in EOC-20 cells supplemented with conditioned media from HT-22 cells treated with recombinant TGFβ1, GW788388, or SIS3. *p < 0.05 compared to EOC-20 supplemented with basal HT-22 conditioned media. #p < 0.05 compared to EOC-20 supplemented with TGFβ1-treated HT-22 conditioned media. n = 3 for mRNA analyses and n = 7 for phagocytosis activity assay

Back to article page