Skip to main content
Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model

Fig. 1

Repeated NTG administration induced basal hypersensitivity and acute hyperalgesia. a Drug administered in the first experiment. C57Bl/6J mice were administered nitroglycerin (NTG; 10 mg/kg, i.p.) every 2 days for 9 days, and saline as control. b, c Basal mechanical responses of periorbital area and hind paw, as assessed prior to NTG or saline administration, significantly decreased in the NTG group. Statistical analyses were performed by two-way ANOVA; ***p < 0.001 (n = 8 mice per group). d, e NTG administration produced significant hyperalgesia of periorbital area and hind paw in mice tested 2 h after NTG. Statistical analyses were performed by two-way ANOVA, ***p < 0.001 (n = 8 mice per group)

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094