Table 2 Ultrastructural analysis of microglial cell bodies in healthy (APP-H), dystrophic (APP-D), and plaque-associated with dystrophy (APP-P) regions of APPSwe-PS1Δe9 mice
From: Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology
APP-H | APP-D | APP-P | |
|---|---|---|---|
Mean ± SEM | Mean ± SEM | Mean ± SEM | |
Area (μm2) | 19.58 ± 1.53 | 21.52 ± 1.80 | 27.15 ± 2.38~ |
Perimeter (μm) | 23.08 ± 1.24 | 23.87 ± 1.64 | 30.5 ± 3.76 |
Circularity (a.u.) | 0.482 ± 0.026 | 0.519 ± 0.033 | 0.459 ± 0.034 |
Roundness (a.u.) | 0.546 ± 0.03 | 0.647 ± 0.032 | 0.625 ± 0.031 |
Solidity (a.u.) | 0.836 ± 0.018 | 0.856 ± 0.018 | 0.822 ± 0.194 |
Lipid body (n) | 0.75 ± 0.22 | 0.429 ± 0.158 | 0.269 ± 0.142 |
Fibrillar materials inclusion (n) | 0 | 0 | 1.577 ± 0.223~~~### |
Phagocytic (%) | 0.75 ± 0.083 | 0.786 ± 0.079 | 0.846 ± 0.072 |
Total inclusion (n) | 1.536 ± 0.209 | 1.536 ± 0.215 | 2.077 ± 0.228 |
Non-empty inclusion (n) | 0.857 ± 0.18 | 0.679 ± 0.186 | 1.808 ± 0.192~~### |
Empty inclusion (n) | 0.857 ± 0.191 | 1.071 ± 0.205 | 1.00 ± 0.184 |
ER dilation (n) | 0.714 ± 0.177 | 0.500 ± 0.159 | 1.231 ± 0.224# |
Extracellular debris (n) | 0.429 ± 0.174 | 1.179 ± 0.236~ | 0.962 ± 0.251 |
Primary lysosome (n) | 0.286 ± 0.162 | 0.174 ± 0.050 | 0.154 ± 0.091 |
Secondary lysosome (n) | 0.679 ± 0.21 | 0.50 ± 0.174 | 0.462 ± 0.177 |
Tertiary lysosome (n) | 0.75 ± 0.213 | 0.321 ± 0.146 | 0.115 ± 0.085~ |
Total lysosome (n) | 1.25 ± 0.27 | 0.714 ± 0.22 | 0.577 ± 0.185 |