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Table 2 Ultrastructural analysis of microglial cell bodies in healthy (APP-H), dystrophic (APP-D), and plaque-associated with dystrophy (APP-P) regions of APPSwe-PS1Δe9 mice

From: Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology

  APP-H APP-D APP-P
Mean ± SEM Mean ± SEM Mean ± SEM
Area (μm2) 19.58 ± 1.53 21.52 ± 1.80 27.15 ± 2.38~
Perimeter (μm) 23.08 ± 1.24 23.87 ± 1.64 30.5 ± 3.76
Circularity (a.u.) 0.482 ± 0.026 0.519 ± 0.033 0.459 ± 0.034
Roundness (a.u.) 0.546 ± 0.03 0.647 ± 0.032 0.625 ± 0.031
Solidity (a.u.) 0.836 ± 0.018 0.856 ± 0.018 0.822 ± 0.194
Lipid body (n) 0.75 ± 0.22 0.429 ± 0.158 0.269 ± 0.142
Fibrillar materials inclusion (n) 0 0 1.577 ± 0.223~~~###
Phagocytic (%) 0.75 ± 0.083 0.786 ± 0.079 0.846 ± 0.072
Total inclusion (n) 1.536 ± 0.209 1.536 ± 0.215 2.077 ± 0.228
Non-empty inclusion (n) 0.857 ± 0.18 0.679 ± 0.186 1.808 ± 0.192~~###
Empty inclusion (n) 0.857 ± 0.191 1.071 ± 0.205 1.00 ± 0.184
ER dilation (n) 0.714 ± 0.177 0.500 ± 0.159 1.231 ± 0.224#
Extracellular debris (n) 0.429 ± 0.174 1.179 ± 0.236~ 0.962 ± 0.251
Primary lysosome (n) 0.286 ± 0.162 0.174 ± 0.050 0.154 ± 0.091
Secondary lysosome (n) 0.679 ± 0.21 0.50 ± 0.174 0.462 ± 0.177
Tertiary lysosome (n) 0.75 ± 0.213 0.321 ± 0.146 0.115 ± 0.085~
Total lysosome (n) 1.25 ± 0.27 0.714 ± 0.22 0.577 ± 0.185
  1. a.u. arbitrary unit, n number per microglial cell body. ~ significant difference from APP-H; # significant difference from APP-D