Fig. 2

Proposed model of rMDD (schematic). Segregation of the anterior and posterior DMN could be an indicator of recurrent depression. Increased functional connectivity between the anterior DMN and the salience network may be an early sign of depression recurrence. Decreased functional connectivity between the posterior DMN and central executive networks is unique to rMDD. ACC, anterior cingulate cortex; AI, anterior insula; dlPFC, dorsolateral prefrontal cortex; dmPFC, dorsomedial prefrontal cortex; DMN, default mode network; mPFC, medial prefrontal cortex; PCC, posterior cingulate cortex; PCu, precuneus;; rMDD, recurrent major depressive disorder