Fig. 8

NOX activity in wild type mice treated with IL-4 after glutamate administration. NOX activity was evaluated in WT mice treated with NaCl 0.9% (S.S.), only glutamate (− IL-4) or glutamate + 0.7 ng/mL of interleukin-4 (+IL4); the determination of NOX activity was measured by the fluorescence resulting from the dihydroethidium (DHE) oxidation in striatal homogenates of mice from 0.5 to 24 h (0.5, 1, 3, 6, 12, and 24 h) after glutamate administration. Data are expressed as fold change of fluorescence relative to saline without IL-4. Values are means ± SEM of three independent experiments. *p < 0.05 vs the corresponding saline control; ^ϕp < 0.05 vs the corresponding time of mice treated with glutamate alone