Fig. 5

Assessment of gross organ weight revealed that paraquat reduced liver weight (a), while increasing lung weight (c) in wild-type (WT) mice, but these changes were completely absent in LRRK2 knockout (KO) mice. Levels of the inflammatory actin regulator protein, WAVE2, were reduced in the liver of LRRK2 null mice, relative to WT animals (b). Whereas WAVE2 levels in the lungs were reduced by paraquat in WT mice, no such effect was apparent in LRRK2 KOs (d). Finally, paraquat provokes a significant elevation of plasma IL-6 in WT mice, but LRRK2 KO prevented this effect (e). *p < 0.05, relative to respective saline-treated controls; ⁺p < 0.05 differences between genotypes