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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta

Fig. 7

LPS does not interact with the amyloid pathway in OHSCs. LPS treatment does not alter APP mRNA expression levels (p = 0.20) (n = 7) (a). ELISA analysis of OHSC medium reveals that LPS treatment reduces the production of Aβ1–42 (two-way ANOVA: effect of treatment p = 0.053 (n = 4)) (b) whilst IL1β application does not influence Aβ1–42 accumulation (two-way ANOVA effect of treatment p = 0.56 (n = 4)) (c). Error bars = mean ± SEM

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