Fig. 7From: Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 betaLPS does not interact with the amyloid pathway in OHSCs. LPS treatment does not alter APP mRNA expression levels (p = 0.20) (n = 7) (a). ELISA analysis of OHSC medium reveals that LPS treatment reduces the production of Aβ1–42 (two-way ANOVA: effect of treatment p = 0.053 (n = 4)) (b) whilst IL1β application does not influence Aβ1–42 accumulation (two-way ANOVA effect of treatment p = 0.56 (n = 4)) (c). Error bars = mean ± SEMBack to article page